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Fertility Drugs

image Many medications are used to treat infertility. The terminology "fertility drug" usually refers to products that induce, enhance, or regulate ovulation.

 

  • FSH ( follicle stimulating hormone ) is an injected fertility medication that stimulates and supports the development of multiple eggs. Used in IVF and stimulated IUI.
  • Clomid is also a commonly prescribed fertility drug that can establish normal ovulation in some women.
  • Metformin is an effective fertility drug for lowering insulin levels in some women with PCOS. Normalizing insulin levels allows normal ovulation to occur.
  • Human chorionic gonadotropins ( hCG ) are an injected hormone used to induce ovulation.
  • Other fertility drugs, such as progesterone, are used to promote the development of the endometrium to adequately support the growing embryo.
  • Corticosteroids sometimes are used to treat immune disorders that can cause the production of antisperm antibodies.
  • Antibiotics are used to treat reproductive tract infections in the male and female.
  • Many other medications may be used to treat diseases that can affect fertility, such as insulin for diabetes.

FSH - Injected Hormones
Follicle stimulating hormone is administered by injection and stimulates the recruitment and development of ovarian follicles that contain the eggs. FSH is naturally produced by the pituitary gland upon stimulation by gonadotropin releasing hormone that is produced by the hypothalamus.
Gona l- F is "pure recombinant" FSH compounds derived from genetically engineered mammalian cell cultures. They are administered subcutaneously and are the preeminent FSH products due to their high purity and activity.

FSH is used in virtually all assisted reproductive technology ( IVF ) cycles to stimulate the development of multiple eggs. Many eggs are needed to insure fertilization and the development of viable embryos for transfer as some eggs are unavoidably damaged during the handling process. FSH is also employed in stimulated intrauterine insemination ( IUI ) cycles.

The dosage of FSH is highly dependent upon each patient's response and often changes during the stimulation cycle. Dosage is influenced by follicular size and number, which is monitored by ultrasound. Estrogen increases in proportion to the number and size of follicles; its measurement helps determine the optimal dosage for each patient.


Lupride

Luprideis a GnRH agonist ( blocks the production of FSH and LH after several days of treatment ) administered according to individual treatment protocols often late in the preceding menstrual cycle for suppression of endogenous FSH ( produced by the patient ) prior to an induction cycle. Lupride given in the early follicular phase of the cycle creates a "rebound effect" leading to a better response to external FSH ( injections ), as in the flare or "short" protocol. Patients on the flare protocol begin GnRH agonists at approximately the same time they begin stimulation drugs.

Lupride eliminates the LH surge, which is the hormonal event signaling ovulation. A premature surge can cause ovulation before the follicles are at the appropriate stage for the IVF ( assisted reproductive technology ) procedure causing cycle cancellation.
With Lupride, the reproductive endocrinologist has maximum control over the "endocrine events" occurring during the stimulation cycle thus maximizing the chance of successful egg retrieval and subsequent conception. Lupride also treats endometriosis by lowering the circulating levels of estrogen, which is required for endometrial tissue growth.

Ganirelix and Cetrotide
Ganirelix and Cetrotide are GnRH antagonists ( blocking the effect of GnRH ) that immediately suppress luteinizing hormone ( LH ). These medications are initiated during the later part of stimulation cycle when the follicles begin to increase in size, whereas Lupride requires ten to twenty days of treatment in the previous cycle. Both antagonists and agonists can be used to eliminate a premature LH surge.

Luveris
Luveris ( lutropin alfa ) is a pure luteinizing hormone ( recombinant human LH ) that treats female infertility. It is indicated for use in combination with human follicle - stimulating hormone ( hFSH ), like Gona l - F, for the stimulation of follicles in the ovaries of women with severe LH and FSH deficiency. Luveris allows physicians to tailor LH administration to individual needs, offering treatment flexibility.

Pregnyl, Ovidrel ( human chorionic gonadotropins, hCG )
Human chorionic gonadotropins ( hCG ) [ Pregnyl ] mimics LH and induces ovulation after the administration of gonadotropins in an assisted reproductive technology ( ART ) cycle. Ovulation occurs precisely 36 hours after administration; egg retrieval is timed between thirty - four to thirty - five hours after ovulation. Precise timing is needed to insure the successful fertilization of the eggs. Ovidrel is derived from genetic recombinant technology and due to its purity can be administered subcutaneously.

Progesterone
Progesterone is a hormone administered after egg retrieval to support the development of the endometrium. Progesterone stimulates an increase in the thickness of the endometrium and increases its blood supply, thus better preparing it to accept a developing embryo. Progesterone occurs naturally and is secreted by the corpus luteum, the small structure formed by the ovarian follicle after ovulation. A progesterone deficiency can occur after ovulation, referred to as a luteal phase defect, and can cause pregnancy loss.
Progesterone is available in several forms including injection ( intramuscular in oil ), gel, vaginal suppository and as micronized oral capsules.

Estrogen
Estrogen stimulates the endometrium to thicken and increase its blood supply. Externally administered, estrogen prepares the endometrium for cryopreserved - thawed embryo transfer cycles and for the recipients in donor egg cycles. Estrogen preparations include estradiol patches and pills.

   
 
 
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female infertility
Infertility in kerala
Improve fertility
Reason for infertility
IUI Cost
ICI in kerala
ICSI videos
IVF and ICSI
Infertility and ICSI
IVF Guide
About Surrogacy
Terms and Condition
Who Donate the Egg
Donor Egg Cost
Donor Sperm Procedure
Laparoscopy Procedure
What is embryo?
Low Sperm count